Itachi has a disease. There is a lack of knowledge about the disease. Itachi overcame the disease with another drug to complete his plot on Sasuke, but the details are never revealed.
The disease is briefly described in Chapter 401 of the original Naruto manga. Sasuke’s brother was “suffering from an illness, well aware of his impending death” and by definition “prolonged his life on drugs”.
Itachi’s illness was not revealed until the end of the account. During his war with Sasuke, it was revealed that his problems were caused by excessive use of the Mangekyo Sharingan. However, his state of causing a near-death catastrophe showed that he was not connected to the Jutsu.
Why did Itachi die so easily?
Itachi’s long term strategy involved allowing Sasuke to win the war and build his Mangekyo Sharingan. Itachi established Sasuke as a hero who saved the Leaf Village by joining the Akatsuki. Because Itachi allowed Sasuke to defeat her, she died instantly. The dignity of the Uchiha family was restored.
Itachi fought, killed, or fled countless famous ninjas. Even though Sasuke was the strongest during their fight, Itachi was probably still holding his own. If Itachi wanted to, he would have defeated Sasuke despite having a smaller shareholder.
What if Itachi was never sick?
Things would probably be the same if Itachi had never been sick. The illness caused the two to quickly meet again. Itachi knew very well that Sasuke’s hunt would not end. To conspire against Sasuke, he used “medicine” to prolong his life. Itachi decided that the most important way to give Sasuke new skills while renovating the Uchiha name was self-sacrifice.
Itachi was suffering from an illness. Details were not released, but she had to take medication to survive.
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